Drug Resistance in Staphylococcus aureus
Overview
Staphylococcus aureus bacteria exhibit increasing resistance to antibiotics such as methicillin and tetracycline. Understanding where, when and how this drug resistance is happening is important, particularly in light of the transmission of drug resistance in healthcare settings and livestock production. Several research projects focus on this topic, in collaboration with CADRE at the Iowa City Veterans Affairs Health Care System and with Dr. Tara Smith of Kent State University..
S. aureus in healthcare settings
Carrel, M., Perencevich, E.N. & David, M.Z. Emergence and Spread of USA300 MRSA, United States, 2000-2013, From Published Reports on 33,543 Isolates. Emerging Infectious Diseases. Online Ahead of Print.
Eko, K., Forshey, B., Carrel, M., Schweizer, M., Perencevich, E., & Smith, T. (2015) Molecular characterization of methicillin-resistant Staphylococcus aureus (MRSA) nasal colonization and infection isolates in a Veterans Affairs hospital. Antimicrobial Resistance & Infection Control. 4:10. 10.1186/s13756-015-0048-5.
An ongoing project explores the connections between MRSA colonization and infection and proximity to swine farms in Iowa, Minnesota and North Carolina.
Eko, K., Forshey, B., Carrel, M., Schweizer, M., Perencevich, E., & Smith, T. (2015) Molecular characterization of methicillin-resistant Staphylococcus aureus (MRSA) nasal colonization and infection isolates in a Veterans Affairs hospital. Antimicrobial Resistance & Infection Control. 4:10. 10.1186/s13756-015-0048-5.
An ongoing project explores the connections between MRSA colonization and infection and proximity to swine farms in Iowa, Minnesota and North Carolina.
S. aureus and livestock production and products
Nair R, Wu J; Carrel M; O’Brien A; Quick M; Farina S; Wardyn S; Thapaliya D; Grenier D; Smith TC. (2016) Prospective multicenter surveillance for Staphylococcus aureus infections, 2011-2013. Diagnostic Microbiology and Infectious Diseases, in press.
Carrel, M., Schweizer, M.L., Sarrazin, M.V., Smith, T.C., & Perencevich, E.N. (2014) Residential proximity to large swine confined animal feeding operations is associated with increased risk of MRSA colonization at time of hospital admission in rural Iowa veterans. Infection Control & Hospital Epidemiology. 35 (2), 190-192.
Warden, S.E., Forshey, B., Farina, S., Kates, A., Nair, R., Quick, M., Wu, J., Hanson, B., O’Malley, S., Shows, H., Heywood, E., Beane-Freeman, L., Lynch, C., Carrel, M. & Smith, T. (2015) Swine farming is a risk factor for infection with and high levels of carriage of multi-drug resistant Staphylococcus aureus. Clinical Infectious Diseases. doi: 10.1093/cid/civ234.
An ongoing USDA-funded project explores the connections between S. aureus in people and in meat sold in local grocery stores.
Carrel, M., Schweizer, M.L., Sarrazin, M.V., Smith, T.C., & Perencevich, E.N. (2014) Residential proximity to large swine confined animal feeding operations is associated with increased risk of MRSA colonization at time of hospital admission in rural Iowa veterans. Infection Control & Hospital Epidemiology. 35 (2), 190-192.
Warden, S.E., Forshey, B., Farina, S., Kates, A., Nair, R., Quick, M., Wu, J., Hanson, B., O’Malley, S., Shows, H., Heywood, E., Beane-Freeman, L., Lynch, C., Carrel, M. & Smith, T. (2015) Swine farming is a risk factor for infection with and high levels of carriage of multi-drug resistant Staphylococcus aureus. Clinical Infectious Diseases. doi: 10.1093/cid/civ234.
An ongoing USDA-funded project explores the connections between S. aureus in people and in meat sold in local grocery stores.